Researchers have uncovered the biological bridge connecting psychological stress to rheumatoid arthritis flares during remission. Stress activates the sympathetic nervous system to stimulate brown fat, releasing the inflammatory cytokine IL-6 into circulation; this in turn signals joint synoviocytes to recruit destructive neutrophils, reigniting localized inflammation without relying on classical autoimmune lymphocytes.
Endometriosis & MCAS
MCAS and endometriosis may overlap through mast-cell activity that amplifies inflammation and nerve sensitivity.